Omics · study · 2026
Epigenomic profiling of H3K9me3 and H3K27ac across melanoma cell lines with different mutational backgrounds
Listed in NCBI GEO
Melanoma is a genetically and phenotypically heterogeneous cancer, and changes in chromatin state have been implicated in melanoma progression, phenotypic plasticity, and tumor behavior.
Description
To investigate the epigenetic landscape associated with melanoma aggressiveness and mutational background, we performed ChIP-seq for the active chromatin mark H3K27ac and the repressive chromatin mark H3K9me3 in five human melanoma cell lines: SK-Mel-19, SK-Mel-29, SK-Mel-103, UACC-62, and UACC-257.
These cell lines represent melanomas with different degrees of aggressiveness and distinct mutation profiles. Our analysis revealed differential patterns of H3K27ac across the cell lines, suggesting that enhancer-associated chromatin states are linked to mutation-dependent transcriptional regulation in melanoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329231 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329231 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1458169 ncbi.nlm.nih.gov/bioproject/PRJNA1458169 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329231 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |