Table 1_Estimated plasma volume status and the risk of 30-day mortality among patients with traumatic brain injury: analysis from the MIMIC-IV database.docx

This analysis aimed to examine the association of estimated PVS (ePVS) with mortality risk among traumatic brain injury (TBI) patients.</p>Methods<p>This retrospective cohort analysis extracted TBI patient data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database spanning 2008–2022. ePVS was calculated using the Duarte formula (Duarte-ePVS) and the Kaplan–Hakim formula (KH-ePVS), respectively.

The associations of Duarte-ePVS and KH-ePVS with 30-day mortality risk among TBI patients were examined via Cox regression analyses. The non-linear associations of ePVS with 30-day mortality were analyzed via the restricted cubic splines (RCS) curve.</p>Results<p>The analysis cohort comprised 1,440 TBI patients, survival outcomes showed 247 (17.15%) deaths and 1,193 (82.85%) survivors at 30-day follow-up. A 1-SD (standard deviation) increase in KH-ePVS levels [HR (95%CI) = 1.17 (1.02–1.34)] and KH-ePVS levels ≥11.458 [HR = 1.43 (1.06–1.95)] were linked to an elevated risk of 30-day mortality.