Table 1_Factors associated with orthostatic hypotension presence and severity in multiple system atrophy: a cross-sectional study.docx

We investigated factors independently associated with OH and severe OH in MSA, and assessed the consistency of these associations across subtypes.</p>Methods<p>We examined the clinical data of 242 MSA patients who had blood pressure evaluations to assess OH. We analyzed the clinical data of MSA patients with and without OH, as well as those with mild and severe OH, focusing on clinical characteristics and brain MRI features to identify factors associated with OH presence and severe OH.</p>Results<p>OH was present in 136 patients (56.2%).

MSA-C subtype (OR = 2.42, 95% CI = 1.33–4.43, p = 0.004), probable MSA (OR = 2.68, 95% CI = 1.49–4.80, p = 0.001), and higher UMSARS-I scores (OR = 1.10, 95% CI = 1.03–1.17, p = 0.005) were independently associated with the presence of OH. Among OH-positive patients, male (OR = 2.57, 95% CI = 1.21–5.44, p = 0.014) and higher NMSS scores (OR = 1.06, 95% CI = 1.02–1.11, p = 0.009) were independently associated with severe OH, whereas MSA subtype was not.