Omics · study · 2026
MAIT cells at different developmental stages egress the thymus to colonize specific tissues and sense increases in peripheral ligands
Listed in NCBI GEO
MAIT but not iNKT cells can be selected by thymic epithelial cells, while both require CD4+CD8+ thymocytes for maturation.
Description
MAIT and iNKT cells have similar developmental dynamics and thymic-residency properties but proliferate at different developmental stages.MAIT cells exit the thymus in an S1PR-dependent manner at different maturation stages to colonize specific peripheral organs.PLZF+Tbet-RORgt- MAIT cells preferentially colonize the intestine in a CCR9-dependent manner.Thymic output contributes to peripheral MAIT and iNKT cell numbers at steady state.
Thymic MAIT17 cells are activated and expand in colitis and after bacterial exposure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308509 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308509 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1330796 ncbi.nlm.nih.gov/bioproject/PRJNA1330796 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308509 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |