Omics · study · 2026
The TENT5A–ATXN2 axis modulates cellular survival during heat stress.
Listed in NCBI GEO
Stress conditions elicit the formation of different kinds of stress granules.
Description
The assembly and composition of heat-induced stress granules remain poorly characterized. Here, we show that the cytoplasmic RNA polyadenylases TENT5A regulate the formation and function of ATXN2-positive heat-induced stress granules.
Tent5a mRNA expression increases when somatic and germ cells are exposed to temperatures between 40°C and 42°C, but not upon exposure to other stressors. TENT5A decreases ATXN2 levels by reducing Atxn2 mRNA translation and accelerating ATXN2 protein decay. Upon heat exposure of the testis, ATXN2-positive stress granules are formed in pre-meiotic and meiotic cells independently of the presence of G3BP1 and the heat stress response protein DAZL.
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Depletion of TENT5A leads to increased cell-type-specific formation of ATXN2-positive stress granules and differentially regulates cell survival. In sum, TENT5A inhibits the formation of ATXN2-positive granules to modulate the heat shock response in vivo.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311487 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311487 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1369545 ncbi.nlm.nih.gov/bioproject/PRJNA1369545 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311487 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |