<p>Improving synthesis performance by enhancing transcription or translation.</p>

<p>Two enhancements are compared to the basic (black) experimental data fitted model (<a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g005" target="_blank">Figs 5</a> and <a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g006" target="_blank">6</a>), attempting to predict what limits the synthesis response <i>in vivo</i>. Accelerating transcription (red) produces a much faster upregulation of mRNA content and synthesis rate, reducing store depletion but depending on a larger mRNA capacity.

Increasing the proportional translation rate (blue) similarly produces a faster upregulation of synthesis, with a more rapid depletion of mRNA content resulting in a lower equilibrium level. This reduces store depletion but likely depends on a translation rate which is beyond the capability of the cells.</p>