Omics · study · 2026
A Novel Therapeutic Agent: Harnessing Macrophage Polarization to Combat Sepsis and Alleviate Lung Injury
Listed in NCBI GEO
Sepsis is a complex syndrome characterized by dysregulated immune responses, with macrophage polarization being pivotal in its immunomodulation.
Description
Lung injury is a prevalent and severe consequence in sepsis. This research delved into the therapeutic potential of JSNPs.
Initially, investigations involving bioinformatics analysis and JHU083 treatment revealed that while JHU083 extended septic mice's survival, it had limited impact on lung injury.Subsequently, studies on JSNPs showed it could improve sepsis and lung injury in CLP and LPS models. Mechanistically, JSNPs promoted macrophage polarization towards the anti - inflammatory M2 phenotype, safeguarding neurons from sepsis - induced lung injury.
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Further experiments demonstrated that JSNPs's protection of lung neurons was M2 macrophage dependent, and macrophages released neurotrophic factors under JSNPs's influence to shield neurons. Overall, JSNPs emerges as a promising candidate for treating sepsis and its associated lung injury.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296887 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296887 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1261887 ncbi.nlm.nih.gov/bioproject/PRJNA1261887 ↗
project · from NCBI GEO
- PubMed 41698047 pubmed.ncbi.nlm.nih.gov/41698047 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296887 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |