Investigation and development of novel exposome informatics methodologies and solutions for the analysis and integration of phenome, genome and exposome data

However, the exposome field, as a more recently emerging domain, has still to receive the same level of informatic methodologies and tools from biomedical informatics. <br><br>This thesis investigates the following hypothesis ‘Biomedical informatics and open data can be leveraged to fill existing methodological gaps and investigate the exposome’, to fulfil an existing knowledge gap in exposome research. <br><br>This thesis therefore details the creation of a data-driven infrastructure which integrates the relationships between the exposome, genome and phenome through investigation and development of new methodologies and solutions, which utilise open-source data. <br><br>The Phexpo Suite is a collective representation of the cumulative work of the developed methodologies presented in the thesis.

The Phexpo Suite, where Phexpo is derived from ‘phenotype-exposome’, is an informatics resource that provides the ability to identify, analyse and explore the relationships between different components of the exposome (chemical compounds, physical phenomena or socio-economic factors) and phenome, through integration with the genome.<br><br><i>Thesis is embargoed until 31 December 2027</i>.<br><br>