Comprehensive analysis of the biological properties of BIOGF1K via the construction of a competing endogenous RNA network

However, the overall molecular regulation mechanism of protection in human skin epidermis remains unclear. Therefore, in this study, we performed functional ceRNA network analysis to reveal the biological properties of BIOGF1K in skin cells by unravelling the associated complex molecular regulations.

We constructed a BIOGF1K-associated ceRNA network by integrating interactions among differentially expressed long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in BIOGF1K-treated epidermal keratinocytes. We obtained the core ceRNA sub-network by performing protein-protein interaction analysis. The evaluation of the core genes in the ceRNA sub-network demonstrated that BIOGF1K regulates genes to enhance anti-inflammatory processes, cell cycle, and DNA repair.