Omics · study · 2026
Semaglutide Slows Epigenetic Aging in a Randomized Trial of HIV-Associated Lipohypertrophy
Listed in NCBI GEO
Genome-wide DNA methylation profiling of PBMC samples from people living with HIV HIV-1 infection impacts biological aging, and epigenetic clocks highlight epigenetic age acceleration in people with HIV.
Description
Despite evidence indicating Glucagon-like peptide-1 receptor agonist in beneficial HIV-associated cardiometabolic outcomes, effects on aging biomarkers in HIV epigenetic studies is a major gap in knowledge. Hence, we generated a representative epigenetic dataset to examine Glucagon-like peptide-1 receptor agonist in epigenetic ageing and relationships to clinical phenotypes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327270 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327270 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1450086 ncbi.nlm.nih.gov/bioproject/PRJNA1450086 ↗
project · from NCBI GEO
- PubMed 42156721 pubmed.ncbi.nlm.nih.gov/42156721 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327270 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |