Omics · study · 2026
Distince macrophage subpopulations in mouse wound healing
Listed in NCBI GEO
Monocytes and macrophages displaying distinctive phenotypes may be pivotal in coordinating the transition between different stages of wound healing.
Description
RNAseq results showed that day 1 macrophages segregated from day 4 and 7 macrophages, and that on days 4 and 7 macrophages segregated primarily based on F4/80-low versus F4/80-high phenotype. TNF and IL-4 pathways converge in F4/80-low macrophages at 4 days after skin wound healing, these F4/80-low macrophages express inflammatory, MHC class II and a subset of IL-4 target genes.
Footprinting analysis on ATAC-seq data revealed enrichement of both NFKB1 and STAT6 in F4/80-low macrophages at 4 dp, whereas the overall differences in transcription factor binding between F4/80-high and F4/80-low macrophages diminished by 7 dpi.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287605 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287605 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1213809 ncbi.nlm.nih.gov/bioproject/PRJNA1213809 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE287605 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |