Holotomographic microscopy - Halting the Reverse Mode: NCX Inhibition as a Neuroprotective Strategy against Oxaliplatin-Induced Peripheral Neurotoxicity

These videos show primary adult mouse DRG neuronal cultures exposed to OHP at 7.5 or 25 µM. Refractive index-based imaging captures neurite fragmentation and degeneration, morphological features consistent with necroptosis, and autophagic vacuoles. Images were acquired using a 5 × 5 grid scan, with each grid measuring 90 × 90 µm, every 15 min for 28 h at 7 fps, from 24 to 52 h after OHP incubation.