Structure · dataset · 2026
The Convergent Synthetic Efforts toward Knightol and a Simplified Analog
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acs.joc.6c01838.s001
We report our efforts toward the convergent total synthesis of the cembranoid diterpene (−)-knightol, a marine natural product reported to exhibit antibiofilm activity against <i>Staphylococcus aureus</i>, and a rationally designed aryl analog, <i>m</i>knightol.
Description
Our strategy was guided by a two-phase approach involving construction of the macrocyclic framework, followed by selective epoxidation and further diversification.
Both targets were designed to arise from common western fragment building blocks and an eastern fragment accessible on a gram scale. A scalable cross-electrophile coupling provided efficient access to an advanced intermediate en route to the cyclophane and enabled evaluation of key late-stage transformations.
Links
Where it is published
- DOI doi.org/10.1021/acs.joc.6c01838.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Inorganic chemistry · Inorganic chemistry · Inorganic chemistry · Life Sciences · Life Sciences · Life Sciences · Ocean & Atmospheric Science · Ocean & Atmospheric Science · Ocean & Atmospheric Science · Research, science and technology policy · Research, science and technology policy · Research, science and technology policy
Provenance · 3 source records, 23 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34032113 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34032113 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34032113 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3402 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |