Data · dataset · 2014
Ethyl mercury induces Ca 2+ uptake through the P2×7 receptor in a mouse cerebellar microglia cell line
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Many observations are reported that organic mercury compounds are involved in increasing intracellular Ca 2+ levels.
Description
However, the issue of which substances on the cell membrane participate in the Ca 2+ uptake that is induced by ethyl mercury is unclear. The findings of this study suggest that the P2X receptor participates in this process.
The uptake of Ca 2+ by C8-B4 cells was induced in the presence of ethyl mercury. Ca channels in the cell membrane were not affected in this process. In contrast, pretreatment with suramin, an antagonist of the P2X receptor, inhibited the Ca 2+ uptake induced by ethyl mercury, and also brilliant blue G, a nonselective antagonist of P2×4, P2×5, and P2×7 receptors.
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In addition, A438079 and A740003, selective antagonists of P2×7 receptor, reduced Ca 2+ uptake, while 5-BDBD, a selective antagonist of P2×4 receptor, did not. Furthermore, the mRNAs of both the P2×4 and P2×7 receptors were expressed in the presence of ethyl mercury, but the P2×5 receptor mRNA was not. These findings suggest that ethyl mercury may induce Ca 2+ uptake through the P2×7 receptor of the cell membrane.
Links
Where it is published
- Repository landing page tandf.figshare.com/articles/dataset/Ethyl_mercury_induces_Ca_sup_2_sup_uptake_thr… ↗
landing page · from DataCite
- Repository landing page tandf.figshare.com/articles/dataset/Ethyl_mercury_induces_Ca_sup_2_sup_uptake_thr… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.1379989 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.1379989.v2 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Attribution 4.0 International creativecommons.org/licenses/by/4.0/legalcode ↗
license · from DataCite
- IsSupplementTo 10.1080/02772248.2015.1028407 doi.org/10.1080/02772248.2015.1028407 ↗
publication · from DataCite
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1379989.v2 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1379989 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1379989.v2 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1379989 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Clinical medicine · Clinical medicine · Health sciences · Health sciences
Related
Provenance · 2 source records, 16 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.1379989 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.1379989.v2 | 15 d ago | JSON v1 |
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|---|---|---|---|
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| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:health-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Chemistry'] |
| concepts[field].local:field:chemistry | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Chemistry'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |