Omics · study · 2026
Effect of hepatic FPN ablation on the liver transcriptome in mice
Listed in NCBI GEO
Iron overload has emerged as a key risk factor for MASLD and metabolic disorders.
Description
We explored the effects of hepatocyte-specific knockout of ferroportin (FPN), the only known iron exporter, on the pathogenesis of MASLD and the associated metabolic dysfunction. To investigate the molecular basis, we carried out RNA-sequencing analysis using liver samples from littermate control and hepatocyte-specific Fpn KO mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE292nnn/GSE292556 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292556 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1240208 ncbi.nlm.nih.gov/bioproject/PRJNA1240208 ↗
project · from NCBI GEO
- PubMed 42048168 pubmed.ncbi.nlm.nih.gov/42048168 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE292556 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |