Omics · study · 2026
m6A RIP-seq of beta-cell s from liver-specific insulin receptor knockout (LIRKO) mice
Listed in NCBI GEO
In type 2 diabetes, pancreatic beta-cells fail to compensate for the presence of insulin resistance in target tissues.
Description
Identifying and studying innovative molecular mechanisms that control the beta-cell adaptation to insulin resistance represent an interesting line of research and are necessary. N6-Methyladenosine (m6A) is the most abundant modification in mRNA and is found virtually in all mammals.
Through m6A-profiling of Control and LIRKO islets we aimed to identify the m6A landscape of the successful beta-cell adaption to insulin resistance.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297196 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297196 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1262981 ncbi.nlm.nih.gov/bioproject/PRJNA1262981 ↗
project · from NCBI GEO
Topics
- Stated by source
- Methylation profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297196 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |