Omics · study · 2026
Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells
Listed in NCBI GEO
BCL11A is a transcription factor crucial for neurodevelopment and hematopoiesis.
Description
It regulates the developmental switch from fetal hemoglobin (HbF) to adult hemoglobin and is a major therapeutic target for sickle cell disease and b-thalassemia. We investigated BCL11A functions in human erythrocyte precursor HUDEP-2 cells.
We treated HUDEP-2 cells (which normally express adult hemoglobin) with inhibitors targeting epigenetic silencing marks - DNA methylation and histone H3 lysine 27 methylation. All treatments, individually or in combination, increased HbF expression to varying degrees.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316022 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316022 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1400486 ncbi.nlm.nih.gov/bioproject/PRJNA1400486 ↗
project · from NCBI GEO
- PubMed 41822826 pubmed.ncbi.nlm.nih.gov/41822826 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316022 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |