Data · dataset · 2026
Quantitative secretome atlas of soluble E-cadherin-driven vascular leakage in the lung pre-metastatic niche of salivary adenoid cystic carcinoma
Listed in ScienceDB
This data set reports the comprehensive, label-free quantitative proteomic profile of conditioned media from high-metastatic (SACC-LM) versus low-metastatic (SACC-83) salivary adenoid cystic carcinoma cells.
Description
LC-MS/MS analysis identified and quantified 5,342 proteins (FDR ≤ 1 % at PSM, protein level), of which 1,847 were significantly differentially secreted (≥ 2-fold change, p ≤ 0.05). Bioinformatic enrichment highlighted over-representation of cell-adhesion molecules, serine hydrolases and apical-junction components, with soluble E-cadherin (sE-cad/CDH1) displaying the strongest up-regulation (22-fold) in the metastatic secretome.
The inventory provides a resource for investigating tumour-derived factors that destabilise endothelial tight-junctions via the Rac2/LIMK/cofilin-1 axis and offers candidate biomarkers for monitoring or targeting the lung pre-metastatic niche in SACC.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.36071 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Biochemistry and cell biology 70% · Mass spectrometry 65%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.36071 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |