<p>List of differentially expressed genes (DEGs).</p>

BRG1 functions in part by integrating calcium-dependent cues via the phosphatase calcineurin (Cn); we also determined that Cn knockdown or pharmacological inhibition of Cn suppressed <i>Tceal7</i> expression and impaired myoblast differentiation. The data suggest that both BRG1-driven chromatin remodeling and Cn signaling converge on <i>Tceal7</i> regulation. Functionally, <i>Tceal7</i> knockdown altered cell proliferation and disrupted myoblast differentiation, at least in part due to reduced expression of <i>Myogenin</i>, which encodes a transcription factor that is an essential differentiation determinant.

RNA-seq analysis revealed broad dysregulation of myogenic, metabolic, and cell-cycle gene programs in <i>Tceal7</i>-deficient cells, including changes in cyclin-dependent kinase-regulated pathways consistent with prior reports linking TCEAL7 to cell-cycle control. Together, these findings identify TCEAL7 as a necessary component of the myogenic regulatory network whose expression is controlled by BRG1-dependent chromatin remodeling and Cn activity.</p></div>