Structured eligibility criteria of breast cancer clinical trials

The method for creating a library and comparing the restrictiveness of criteria has been described in [2]. An interactive visualization of the library, prepared by Rinke Hoekstra can be accessed at semweb.cs.vu.nl/eligibility [3]. The library can be queried using the following SPARQL endpoint semweb.cs.vu.nl:8080/openrdf-sesame/repositories/ct [4] Example of sparql queries are available at [5] .

Enclosed examples allow to i.e.: 1.Find criteria that mention a conceptwith a specific UMLS CUI e.g.“C0029925”(OvarianCarcinoma) 2. Find trials with criteria that match a specific pattern e.g. “At least () since prior ()” 3. Displays a list of all defined patterns 4.

Find trials with criteria that mention a specific drug e.g. “C0039286” (Tamoxifen) in a specific context e.g. as a forbidden prior treatment 5. Find trials with criteria that are more relaxed than a provided one e.g. “bilirubin less than 1.5”