Omics · study · 2026
Chronic Reflux Stress Reshapes the EAC Transcriptional Landscape via APE1
Listed in NCBI GEO
Gastroesophageal reflux disease (GERD) is the predominant risk factor for the development of Barrett’s esophagus and esophageal adenocarcinoma (EAC).
Description
However, the molecular mechanisms driving responses to chronic reflux conditions in EAC remain poorly defined. This study investigates the genome-wide transcriptional reprogramming and molecular stress responses mediated by apurinic/apyrimidinic endonuclease 1 (APE1) in EAC cells (OE33) surviving chronic, reflux-induced stress.
By pairing a 15-day repeated acidified bile salt (rABS) exposure model with subsequent APE1 genetic silencing, this dataset defines the global differential gene expression profiles, altered signaling pathways, and transcriptional networks that depend on APE1 for acquired stress tolerance during sustained reflux insults.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342970 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342970 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1509526 ncbi.nlm.nih.gov/bioproject/PRJNA1509526 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342970 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |