Omics · study · 2026
Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis
Listed in NCBI GEO
Primary cilia serve as sensory hubs that integrate extracellular cues to regulate adipogenesis.
Description
To investigate the underlying transcriptional programs during adipogenic commitment, we performed RNA-seq profiling of primary mouse adipocyte precursors (Lin-CD34+CD29+Sca1+) at distinct stages of adipogenic differentiation. This dataset reveals the dynamic expression of cilia-related genes and uncovers the transient activation of the ERK signaling pathway, providing mechanistic insights into cilium-dependent adipogenic initiation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337570 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337570 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1490426 ncbi.nlm.nih.gov/bioproject/PRJNA1490426 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337570 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |