Metal ion balance and level of serum biochemical, redox, immune parameters after excessive red wine and alcohol consumption in rats

Our study aimed to investigate alterations in metal ion balance, CYP enzyme activities, biochemical, redox, and immune parameters in rats, following red wine or alcohol consumption for 10 days. Wistar rats (N=15) received alcohol and red wine at doses equivalent to those typically consumed by heavy drinkers.

At such intake levels, red wine provides substantial amounts of nutritionally relevant polyphenols and mineral elements (B, Cu, Fe, K, Mn, P). Compared to controls, both alcohol and red wine induced similar changes in most of the parameters, with several notable exceptions. Among the elements, Ca, P and Zn concentrations were significantly elevated in erythrocytes of red wine (4.50±0.45, 29.05±1.19 and 0.566±0.072 µg/g, respectively) and alcohol-treated groups (4.02±0.43, 23.57±0.97 and 0.557±0.123 µg/g) compared to controls (2.44±0.13, 18.76±0.74 and 0.321±0.026 µg/g).