Data · dataset · 2026
Naproxen Dissolution - Permeation
Listed in Riga Stradins University dataverse
Naproxen tablets dissolution (Nalgesin 550 mg) release profiles and permeation (expressed as apparent permeability coefficient, Papp) across different membrane compositions.
Description
With aim to test novel dissolution-permeation setup and apply it to dissolution-permeation studies of poorly soluble drugs. The dissolution-permeation system setup consisted of a compendial USP2 dissolution apparatus (Double ATSXstend, Sotax, Switzerland), a 6-channel peristaltic pump (LabN1-II/AMC6, Shenchen, China) with silicone tubing, and a CHM1 Ussing chamber with a 1.13 cm2 membrane opening (World Precision Instruments, USA).
Two USP2 vessels were used simultaneously one vessel donor compartment, another acceptor compartment. The Ussing chamber was mounted to an in-house built stand and secured with screws. Silicone tubing (FedroTek, China) Ø2 mm, wall thickness 1 mm was connected to the Ussing chamber ensuring a leak-free system.
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The media pumping flow rate was 6 mL/min. The dissolution study was performed using the pharmacopoeial PBS (1000 mL, pH 6.8, KH2PO4, NaOH). Water bath temperature was set at 37 ºC with a paddle rotation speed of 50 RPM.
Off-line sampling and spectrophotometric quantification was performed over 120 minutes. Dissolution-permeation study. Nalgesin 550 mg tablets were dissolved in 1000 mL pH 6.8 PBS in the donor vessel.
The acceptor vessel contained 1000 mL pH 7.4 PBS (KH2PO4, NaOH). A permeable membrane filter was mounted in the Ussing chamber and covered with soy L-α-phosphatidylcholine solution in dodecane. Permeated naproxen in the acceptor media was UV-quantified on-line with sampling every 15 minutes, up to 180 minutes.
The Papp were calculated from the values on the linear part of the permeation curve.
Links
Where it is published
- Dataverse dataset page dataverse.rsu.lv/dataset.xhtml?persistentId=doi%3A10.48510%2FFK2%2FBCKARL ↗
landing page · from dataverse rsu lv
- DOI doi.org/10.48510/fk2/bckarl ↗
DOI / persistent id · from dataverse rsu lv
Catalogue records · 1
- Dataverse API dataverse.rsu.lv/api/datasets/:persistentId/?persistentId=doi%3A10.48510%2FFK2%… ↗
metadata API · from dataverse rsu lv
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Riga Stradins University dataverse | doi:10.48510/FK2/BCKARL | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /subjects |
| created_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| description | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /description |
| publication_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| title | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | /name |
| updated_date | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 | |
| version_label | source · dataverse rsu lv | connector:dataverse_rsu_lv@1.0.0 |