Identification and functional characterisation of an antimicrobial peptide QUB-1529 from the skin secretion of the Asian frog, Hylarana guentheri

From the results, it was shown that QUB-1529 exhibits an excellent antibacterial activity against the Gram-positive bacterium, S. aureus, and the yeast, C. albicans.<br><br>With the rapid rise in antibiotic drug resistance, traditional antibiotics have become increasingly irrelevant in clinical practice despite increasing demand. The discovery of novel antimicrobial peptides may be a solution to this problem. Due to the rapid effects of the antimicrobial peptide on the surface of the bacterial membrane, it is difficult to produce drug resistance.

Therefore, this class of peptide shows great potential to replace conventional antibiotics. This study unequivocally demonstrated that QUB-1529 exhibits an inhibitory effect on the growth of Gram-positive bacteria and shows the medical development potential of these peptides in replacing antibiotics to treat Gram-positive bacterial infections.