Table · dataset · 2026
Data Sheet 1_Beyond mean heart dose: differentiated electrocardiographic manifestations and dosimetric mechanisms of cardiac injury in left-sided versus right-sided breast cancer after intensity-modulated radiotherapy.docx
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Description
Objective<p>To investigate dosimetric exposure variations to the whole heart and substructures between left- and right-sided breast cancer patients receiving intensity-modulated radiotherapy (IMRT), and to evaluate their relationships with post-radiotherapy (post-RT) electrocardiogram (ECG) alterations.</p>Methods<p>Clinical and dosimetric data of 91 breast cancer patients (54 left-sided, 37 right-sided) undergoing postoperative free-breathing IMRT were retrospectively analyzed.
Twelve-lead ECGs were regularly monitored during follow-up. Kaplan-Meier analysis evaluated ECG abnormality-free survival. Receiver operating characteristic (ROC) curves compared the predictive values of mean heart dose (MHD) and left ventricular mean dose (LV D<sub>mean</sub>) for new-onset repolarization abnormalities in left-sided patients, utilizing mathematically derived population-specific split-points.</p>Results<p>Target volume configurations (comprehensive regional and internal mammary node irradiation) drove distinct substructure exposure patterns between sides.
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In left-sided patients, MHD, LV, and left anterior descending artery (LAD) doses were significantly higher than those in right-sided patients (all P < 0.001). Conversely, right-sided patients sustained significantly higher doses to the sinoatrial node (SAN) and right coronary artery (RCA) (all P < 0.001). Left-sided patients had a significantly shorter median ECG abnormality-free survival than right-sided patients (7.0 vs. 12.0 months, P = 0.038).
Among the 60 patients developing post-RT ECG modifications (incidence: 81.5% in left-sided cases), left-sided cases predominantly exhibited repolarization abnormalities (68.2%), whereas right-sided cases primarily presented rhythm abnormalities (62.5%, P = 0.032). In the left-sided subgroup, LV dosimetric parameters (LV D<sub>mean</sub>, LV V<sub>5</sub>–V<sub>80</sub>) were significantly higher in the repolarization group than in the rhythm group (all P < 0.01).
ROC analysis indicated that LV D<sub>mean</sub> outperformed MHD in predicting early repolarization changes (AUC: 0.776 vs. 0.715).</p>Conclusion<p>Early post-RT cardiotoxicity follows a laterality-specific “dual-mechanism model.” Left-sided modifications manifest primarily as acute/subacute repolarization surrogates driven by diffuse LV exposure, whereas right-sided modifications present as rhythm-based stress from focal SAN exposure.</p>
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Where it is published
- DOI doi.org/10.3389/fonc.2026.1901038.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Medicine & Health · Ocean & Atmospheric Science · Social Science
- Inferred from text
- Cancer 75% · Heart 75% · Oncology and carcinogenesis 74%
Provenance · 1 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33827632 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cancer | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (74%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |