Tree Shew Model of Hantaan Virus Infection

This study demonstrates that the tree shrew (Tupaia belangeri) is susceptible to HTNV infection and recapitulates human HFRS renal pathology. Transcriptome analysis revealed HTNV induces host metabolic reprogramming, suppressing de novo lipogenesis and enhancing fatty acid oxidation.

Crucially, fatty acid synthase (FASN), a key lipogenic enzyme, was identified as essential for HTNV replication. FASN knockdown or inhibition (TVB-3664) reduced viral proliferation by disrupting lipid droplet formation and boosting type I interferon responses. Mechanistically, the HTNV nucleocapsid protein (Np) recruits and interacts with FASN to hijack the lipogenic pathway.