Data · dataset · 2026
The therapeutic effects and mechanisms of action of baicalin in sepsis: a systematic review
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.6084/m9.figshare.34041820.v1
<p>Sepsis is a critical medical state considered a life-threatening response to infection, leading to extensive inflammation and potential organ dysfunction.
Description
This systematic review focuses on the therapeutic impact of baicalin on sepsis complications.
Methods
Read the rest (3 more)
This systematic review followed PRISMA guidelines and was registered in PROSPERO. We searched PubMed, Web of Science, Scopus, Embase, and Google Scholar up to May 10, 2026. We included <i>in vitro</i> and <i>in vivo</i> experimental studies of baicalin in sepsis-related models.
Results: Of 669 records, 41 studies met the eligibility criteria. Baicalin consistently reduced oxidative stress markers, pro-inflammatory cytokines, and activation of NF-κB, TLR4, HMGB1, and NLRP3-related pathways, while increasing antioxidant and anti-inflammatory mediators. Several studies also reported improved organ protection and survival.
Conclusions: Baicalin appears beneficial in preclinical sepsis models, but evidence certainty is limited by heterogeneity, a lack of human studies, and the absence of a meta-analysis.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34041820.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Immunology · Immunology · Immunology · Medicine & Health · Medicine & Health · Medicine & Health · Research, science and technology policy · Research, science and technology policy · Research, science and technology policy
Provenance · 3 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34041820 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34041820 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34041820 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:440710 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:3204 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].anzsrc:group:3204 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |