Omics · study · 2026
BUI1, an actin cytoskeleton protein that confers durable and broad-spectrum resistance in rice
Listed in NCBI GEO
The cytoskeleton functions as a dynamic intracellular structural scaffold, enabling cells to rapidly perceive biotic and abiotic stresses.
Description
During plant innate immune responses, the cytoskeleton undergoes actin remodeling. Using the rice-Magnaporthe oryzae pathosystem, we investigated changes in actin organization within host plant cells.
Our results demonstrate that pattern-triggered immunity (PTI), induced by pathogen-associated molecular patterns (PAMPs), triggers a rapid but transient increase in actin filament abundance. This process depends on BUI1, a type-II formin protein. Disruption of actin filaments with latrunculin B not only suppresses this increase but also enhances host susceptibility.
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Furthermore, we show that BUI1 positively regulates broad-spectrum resistance against multiple pathogens by suppressing reactive oxygen species (ROS) scavenging. Together, these findings uncover a key mechanism by which receptor-mediated signaling reorganizes the host cytoskeleton during plant-pathogen interactions.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305236 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305236 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1304888 ncbi.nlm.nih.gov/bioproject/PRJNA1304888 ↗
project · from NCBI GEO
- PubMed 42390795 pubmed.ncbi.nlm.nih.gov/42390795 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305236 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |