Supplemental Material for: Anxiety Symptoms and Risk of Dementia Progression in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

A systematic literature search was performed in Medline and other relevant databases to find cohort studies examining the association between anxiety symptoms and dementia progression in MCI. </p><p dir="ltr">Results: Fifteen cohort studies were included in the systematic review, of which fourteen were included in meta-analyses. Anxiety was significantly associated with an increased risk of all cause dementia, HR = 1.25; 95% CI, 1.11–1.41; p < 0.001, and Alzheimer’s disease, HR = 1.32; 95% CI, 1.16–1.49; p < 0.001, while pooled odds ratios did not show a significant association OR = 1.15; 95% CI, 0.84–1.57; p = 0.39. </p><p dir="ltr">Conclusion: Anxiety symptoms may be associated with an elevated risk of dementia conversion in MCI.

Further large-scale prospective cohort studies are needed to determine the strength and clinical importance of these findings.</p>