Table · dataset · 2026
Data Sheet 1_Small cell transformation during acquired resistance to zongertinib in HER2-mutant non-small cell lung cancer: a case report.docx
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fonc.2026.1934878.s001
Background<p>Small cell transformation (SCT) is a known acquired resistance mechanism to targeted therapies in non-small cell lung cancer (NSCLC) but has not been reported following HER2 tyrosine kinase inhibitor (TKI) therapy.
Description
We report the first case of SCT detected during acquired resistance to zongertinib, a novel selective HER2 TKI, in a patient with HER2-mutant pulmonary enteric adenocarcinoma.</p>Case presentation<p>A 55-year-old never-smoking male with advanced pulmonary enteric adenocarcinoma harboring HER2 exon 20 YVMA insertion (p.Y772_A775dup) and concurrent TP53/RB1 co-mutations received multiple prior lines of therapy.
He obtained partial response to zongertinib. After six months, neuron-specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP) rose with disease progression. Rebiopsy of a progressing lesion revealed SCT with 80% SCLC and 20% adenocarcinoma; genomic profiling retained the original HER2 insertion and TP53/RB1 mutations.
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Following transformation, etoposide plus carboplatin decreased NSE and ProGRP but paradoxically increased carcinoembryonic antigen (CEA). Adding zongertinib reduced CEA, whereas the SCLC component continued to progress. The patient survived 5.6 months after SCT diagnosis.</p>Conclusion<p>This is the first report of SCT emerging during acquired resistance to a HER2 TKI.
Baseline TP53/RB1 co-mutations may identify patients at higher risk for histologic transformation. Dynamic monitoring of neuroendocrine markers facilitates early detection, and mixed histology warrants individualized strategies targeting both tumor subclones.</p>
Links
Where it is published
- DOI doi.org/10.3389/fonc.2026.1934878.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Cancer 75% · Disease 75% · Oncology and carcinogenesis 71%
Provenance · 2 source records, 31 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33992017 | 12 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33992017 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |