CBP/p300 deficiency induces the loss of functional pancreatic α cell mass

Here, α cell-specific deletion of CBP/p300 in mice leads to hypoglucagonemia and hyperaminoacidemia, along with decreased functional pancreatic α cell mass due to impaired cell proliferation, dedifferentiation, and cell loss. The knockout of CBP/p300 blocks glucagon receptor antibody-stimulated α cell proliferation and mTORC1 signaling in mice.

These findings uncover a critical role for CBP/p300 in the maintenance of α cell identity and function.