Data · dataset · 2026
circRNA_013145–miR-185-5p–RhoA Axis: A Novel Mechanism in the Pathophysiology of Diabetes-induced Erectile Dysfunction
Listed in ScienceDB
Circular RNAs significantly impact the pathophysiology of various disorders, but their role in diabetes-induced erectile dysfunction remains unclear.
Description
We examined circular RNA expression profiles in diabetes-induced erectile dysfunction rats, identifying 641 upregulated and 647 downregulated circular RNAs. Quantitative real-time polymerase chain reaction revealed elevated circRNA_013145 levels in rat penile tissues and in high glucose-induced corpus cavernosum smooth muscle cells and human umbilical vein endothelial cells.
Bioinformatics analyses identified the circRNA_013145-miRNA-mRNA regulatory network and its link to the cGMP-PKG and cAMP pathways. Interference with circRNA_013145 in high glucose-induced cells reduced inflammation, oxidative stress, phenotypic transformation, and apoptosis. Further assays confirmed that circRNA_013145 regulates RhoA by sponging miR-185-5p.
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Silencing circRNA_013145 improved diabetes-induced erectile dysfunction symptoms in rats, suggesting it as a potential therapeutic target.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.35767 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.35767 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |