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Omics · study · 2026

hepatocellular carcinoma after glucose-free microvesicle treatment

Listed in NCBI GEO

As tumor progression occurs, liver cancer cells are often in a state of nutrient deprivation, particularly lacking glucose.

Description

We found that microvesicles secreted by liver cancer cells under glucose-free conditions can promote tumorigenesis and progression. The specific mechanism involves enhancing neutrophil expression of PD-L1 and VEGFA, thereby suppressing T cell cytotoxicity and promoting angiogenesis.This phenotype is abolished after Ezrin knockout in liver cancer cells.

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Expression profiling by high throughput sequencing · Mus musculus
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Life Sciences
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Cancer 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE28296814 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title