Omics · study · 2026
Co-delivery of Cisplatin and Bmi1 siRNA via Nanocapsules Overcomes Chemoresistance in Ovarian Cancer
Listed in NCBI GEO
Ovarian Cancer (OC) is one of the gynecological malignancies with the highest mortality rate.
Description
Among the numerous subtypes of ovarian cancer, high-grade serous ovarian cancer (HGSOC) is the most common subtype and has a significant impact on prognosis, accounting for approximately 70%-80% of ovarian cancer-related deaths. Platinum-based chemotherapy combined with paclitaxel is the main approach for treating HGSOC.
However, up to 75% of patients with advanced HGSOC will experience recurrence and eventually develop platinum-based resistance, among which approximately 20% of patients do not respond to first-line platinum-based treatment initially. Studies have shown that Cancer Stem cells (CSCs) play a key role in chemotherapy resistance of ovarian cancer. Bmi1 is an important protein for maintaining the stemness of tumor cells.
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Targeting Bmi1 is regarded as an effective treatment strategy for tumor drug resistance.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318061 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318061 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1416408 ncbi.nlm.nih.gov/bioproject/PRJNA1416408 ↗
project · from NCBI GEO
- PubMed 41922680 pubmed.ncbi.nlm.nih.gov/41922680 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318061 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |