Structure · dataset · 2024
Pax6 co-expresses and gets compartmentalized in the heart of diabetic mice
Listed in Teesside University Research Data Repository
The Paired box (Pax6), a highly conserved transcription factor, and Tgf-β1 are involved in various cellular functions such as differentiation, activation of extracellular matrix proteins, epithelial-mesenchymal transition, production of cytokines, MAPK, NF-kB, PI3K, Tgf-βs, TLRs, and insulin signaling pathways.
Description
In the present study, it was observed that the epicardial, myocardial, and endocardial structures were distorted, and co-expression and compartmentalization of Pax6 and Tgf-β1 occurred in different layers of diabetic mice compared to the control.
In the heart, Pax6 expression promotes cardiac fibroblast differentiation via maintaining Tgf-β1 levels. The Tgf-β1 is a pleiotropic cytokine involved in many biological functions. The ligand of Tgf-β1 and their signaling molecules are necessary for the heart's development and normal cardiovascular function.
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The high level of glucose stimulates Tgf-β1 dependent pathways and activates Tgf-β1 further leading to cardiac fibrosis which includes cardiac hypertrophy through SMAD-dependent and independent (canonical and non-canonical) pathways. Since expression of Tgf-β1 and Pax6 has been proven to be critical for the functional anatomy of the heart, Tgf-β1 and Pax6 might function like tissue-dependent regulation through various signaling pathways or networks.
Results suggest that Tgf-β1 and Pax6 have a crucial role in the differentiation and development of cardiac fibroblasts and also regulate the differentiation of fibroblasts into myofibroblasts via SMAD-dependent and independent (canonical and non-canonical) pathways. However, the maintenance and differentiation of cardiac fibroblasts may lead to novel therapy in some patients with cardiac dysfunction.
Links
Where it is published
- DOI doi.org/10.17632/ngktxkzhw7.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Materials Science · Social Science
- Inferred from text
- Heart 75%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/ngktxkzhw7.1 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |