Omics · study · 2026
Effects of influenza A and SARS-CoV-2 coinfection on interferon stimulated gene expression patterns in primary human nasal epithelial cells
Listed in NCBI GEO
In the winter of 2022/23, influenza and SARS-CoV-2 viruses co-circulated in human populations without non-pharmaceutical interventions, prompting an assessment of their interaction.
Description
Co-infection of the first wave SARS-CoV-2 and influenza led to severe lung damage in animals and more severe disease in humans. However, our understanding of the underlying interaction mechanisms is limited.
Using primary human nasal epithelial cells, we analysed the replication of circulating influenza (IAV H3N2 2021) and SARS-CoV-2 (Omicron BA.5) viruses in sequential co-infections. RNAseq analysis revealed distinct subsets of interferon-stimulated genes induced by Omicron BA.5 and IAV H3N2 in pre-infected cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE237nnn/GSE237576 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237576 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA995764 ncbi.nlm.nih.gov/bioproject/PRJNA995764 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE237576 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |