Omics · study · 2026
Uridine Modulates Gene Expression Programs During RANKL-Induced Osteoclastogenesis in RAW264.7 Cells
Listed in NCBI GEO
Uridine has been implicated in the regulation of metabolic and redox processes, yet its transcriptional effects during osteoclast differentiation remain unclear.
Description
This dataset profiles global gene expression in RAW264.7 cells under three conditions: untreated control, RANKL-induced osteoclastogenesis, and RANKL combined with uridine treatment. The results reveal uridine-responsive transcriptional changes involving osteoclast differentiation, oxidative stress regulation, and PI3K/Akt–FoxO–related pathways, providing mechanistic insight into uridine-mediated modulation of osteoclastogenesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311708 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311708 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370289 ncbi.nlm.nih.gov/bioproject/PRJNA1370289 ↗
project · from NCBI GEO
- PubMed 42125660 pubmed.ncbi.nlm.nih.gov/42125660 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311708 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |