Mouse femur LC-MSMS upon weightlessness

However consequences on B cell development and responses are still under-investigated. Up to now most studies addressing these questions were performed using an amphibian species.

Consequently we used advanced proteomics analysis of femur bone and marrow of mice flown for one month on board the BION-M1 biosatellite to determine whether extreme conditions encountered during a real spaceflight affect B cell development in mice and to examine reversibility of the effects upon return to Earth. Our data revealed that adverse effects on B lymphopoiesis were more marked one week after landing and that this phenomenon was associated with a 41% reduction of B cells in the spleen.