Histological and molecular evidence of the positive performance of chitosan-alginate membranes on skin lesions of hiperglycemic mice

For collagen fibers, the DMCAM group presented mild red-orange birefringence compared to the CTSF and DMSF groups. On the 14th day there was a small concentration of thinner elastic fibers for the DMCAM group, with better reorganized papillary dermis and collagen fibers with better red-orange birefringence and network-shaped orientation, similar to intact skin, with better organization of elastic fibers, sparse throughout the neoderm and with greater presence of elauninic fibers, similar to the elastic fibers of intact skin.

The use of CAM in skin lesions favored tissue repair, through a smaller number of inflammatory cells and mast cells, improving the deposition of collagen and collagen fibers. Demonstrating potential coverage for skin wounds.