Age-Dependent Transcriptomic and DNA Methylation Alterations in Fibroblasts During Resolving and Persistent Lung Fibrosis

Although the model of bleomycin-induced lung fibrosis in young adult mice is often criticized because fibrosis spontaneously resolves, comparisons of this model with aged mice, in which fibrosis persists, can provide important insights into the genes and pathways that modulate persistent vs resolving fibrosis.

Changes in DNA methylation are a prominent feature of aging and pulmonary fibrosis. Here, we explore the differential expression and DNA methylation patterns that occur in lung fibroblasts of young and aged mice during persistent and resolving fibrosis.