Omics · study · 2026
Effect of miR-4800-3p overexpression on gene expression related to metastasis in pancreatic cancer cell lines (MIA PaCa-2 and PSN-1)
Listed in NCBI GEO
Understanding the molecular characteristics of pancreatic cancer liver metastases is essential for advancing individualized treatment strategies.
Description
This study identifies miR-4800-3p as a potential contributor to liver metastasis. miR-4800-3p appears to promote liver metastasis by directly targeting PLAA, inhibiting ubiquitination, and stabilizing METTL3 protein. This process enhances the expression of the oncogene GPRC5A, potentially driving metastatic progression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282572 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282572 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1189157 ncbi.nlm.nih.gov/bioproject/PRJNA1189157 ↗
project · from NCBI GEO
- PubMed 42002588 pubmed.ncbi.nlm.nih.gov/42002588 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE282572 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |