Omics · study · 2026
Hepatic ChREBP is a Driver of Pathological Cardiac Remodeling via Non-Transcriptional Repression of Apolipoprotein M
Listed in NCBI GEO
Pathological cardiac remodeling is a major risk factor for heart failure, and that the hepatic transcription factor ChREBP typically regulates glucose and lipid metabolism by translocating to the nucleus to exert transcriptional regulatory functions.
Description
Furthermore, the liver-secreted protein ApoM exerts cardiovascular protective effects, and inter-organ crosstalk plays a role in systemic homeostasis. This study now reveals that in response to cardiac stress, ChREBP is specifically upregulated in the hepatocyte cytoplasm-not the nucleus-where it interacts with the ER protein SURF4 to inhibit ApoM secretion.
We identify the restoration of this liver-heart axis via the ChREBP-SURF4-ApoM pathway and subsequent activation of cardiac S1P/S1PR1 signaling as a novel mechanistic basis for ameliorating cardiac remodeling, offering a promising therapeutic strategy for heart failure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337074 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337074 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1484005 ncbi.nlm.nih.gov/bioproject/PRJNA1484005 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiac remodeling 75% · Heart 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337074 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiac-remodeling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |