Omics · study · 2026
Nuclear FGF2, Androgen Receptor and Wnt Pathway Activation Define a Targetable Subset of Antiprogestin-Resistant Luminal Breast Cancer
Listed in NCBI GEO
We used PR+ T47D and T47D‑YA cell lines engineered to overexpress FGF2 to investigate FGF2‑driven antiprogestin resistance.
Description
Transcriptome profiling, qRT-PCR, immunohistochemistry, and in vivo assays were performed to assess hormone receptor expression, pathway alterations, and therapeutic response. We evaluated nuclear androgen receptor (AR) and FGF2 in luminal breast cancer specimens.
RNA-seq showed that FGF2 overexpression dysregulated Wnt signaling, downregulated estrogen receptor (ER) and PR, and upregulated AR expression. PR isoform B (PRB) predominated over isoform A, consistent with an antiprogestin-resistant phenotype. FGF2-overexpressing xenografts showed antiprogestin resistance, increased proliferation, and lung metastasis.
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AR and Wnt pathway blockade impaired tumor growth, and combined treatment further reduced tumor and metastatic burden. In clinical samples, nuclear FGF2 correlated with elevated AR levels in ER+PR− and PRB-high tumors.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315149 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315149 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1395058 ncbi.nlm.nih.gov/bioproject/PRJNA1395058 ↗
project · from NCBI GEO
- PubMed 41935240 pubmed.ncbi.nlm.nih.gov/41935240 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315149 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |