Omics · study · 2026
A SINGLE NUCLEOTIDE DELETION DISRUPTS THE TRANSCRIPTIONAL RESPONSE OF THE HAIRLESS GENE TO THYROID HORMONE AND THYROID HORMONE SIGNALLING IN MICE.
Listed in NCBI GEO
The transcription of the Hairless gene, which encodes a histone demethylase, is strongly induced by thyroid hormone in many cell types.
Description
To address the significance of this regulation, we identified a DNA response element in the regulatory sequences of the Hairless gene, which plays a key role in this regulation. A single mutation in this response element proves to be sufficient to alter thyroid hormone signaling in mice.
RNA-seq analysis in the heart and striatum of mice homozygous for this mutation highlights the influence of the Hairless cofactor in thyroid hormone signaling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311836 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311836 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370979 ncbi.nlm.nih.gov/bioproject/PRJNA1370979 ↗
project · from NCBI GEO
- PubMed 41941594 pubmed.ncbi.nlm.nih.gov/41941594 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311836 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |