Omics · study · 2026
Integrated Transcriptomic Profiling of Rectal and Adipose HIV-1 Reservoirs Relative to Matched PBMCs in ART-Treated Individuals
Listed in NCBI GEO
HIV-1 persistence in anatomical reservoirs remains a major obstacle to a functional cure under suppressive antiretroviral therapy.
Description
This study used bulk RNA-seq to characterize host transcriptomic features across matched peripheral blood mononuclear cells (PBMCs), rectal tissue, and subcutaneous adipose tissue (SAT) from ART-treated people with HIV. Transcriptomic profiling revealed tissue-specific remodeling in rectal and adipose reservoirs relative to matched PBMCs, including extracellular matrix remodeling, immunometabolic alterations, and shared PI3K-Akt-related transcriptional features.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336629 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336629 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1482132 ncbi.nlm.nih.gov/bioproject/PRJNA1482132 ↗
project · from NCBI GEO
- PubMed 42483200 pubmed.ncbi.nlm.nih.gov/42483200 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336629 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |