Excel · study · 2026
A randomized controlled trial of intravenous immunoglobulin compared with standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients (VIPAR)
Listed in NCBI GEO
The study included 30 kidney transplant recipients with chronic active antibody-mediated rejection (AMR), randomizing them (15 per arm) to receive prolonged (6-months), high dose (1gm/kg) IVIG, compared with standard of care, which currently is the optimization of baseline immunosuppression.
Description
We found that IVIG therapy reduced progression of our primary outcome measure of histological injury compared to the group receiving no-IVIG.
Histology was assessed using the CADI score across 4 biopsies taken at baseline, 3, 6 and 12-months. There was also relative stabilization of eGFR with IVIG compared to no-IVIG. An additional secondary outcome of note over extended follow-up (5-years) was improved patient survival in the IVIG group.
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Finally, intragraft mRNA expression was assessed using the Nanostring B-HOT panel and there were significant differences in expression between the two groups involving genes associated with B-cells, T-cells, natural killer cells and fibrosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295752 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295752 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1256297 ncbi.nlm.nih.gov/bioproject/PRJNA1256297 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295752 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |