Omics · study · 2026
Stage-specific degradation of cyclin D3 orchestrates myelopoiesis and restrains MPN development [scRNA-seq]
Listed in NCBI GEO
Cyclin D3 is critical for myelopoiesis, with its rapid, stage-specific degradation regulating normal granulocyte-monocyte differentiation.
Description
Using a knock-in mouse model with a degradation-resistant cyclin D3 variant (D3T283A), we show that sustained cyclin D3 levels enhance granulocyte-monocyte output, cause microcytic erythrocytes, thrombocytosis, and extramedullary hematopoiesis. Splenic HSPCs from D3T283A mice exhibit increased self-renewal and competitive repopulation advantage.
Prolonged D3T283A expression drives a high-penetrance myeloproliferative neoplasm, reducing survival.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296132 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296132 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1257849 ncbi.nlm.nih.gov/bioproject/PRJNA1257849 ↗
project · from NCBI GEO
- PubMed 42223968 pubmed.ncbi.nlm.nih.gov/42223968 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296132 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |