Omics · study · 2026
Ascertaining the effect of switching deregulated Myc OFF in KRasG12D/MycER-driven mouse lung tumors
Listed in NCBI GEO
The mechanisms by which inhibition of an oncogenic driver induces tumour regression and tissue resolution is unclear.
Description
In an autochthonous mouse model of lung adenocarcinoma driven by oncogenic Kras and deregulated Myc cooperation, we initiated acute loss of Myc exclusively in the tumour epithelial cells to identify the sequence of events and crosstalk in a tumour and its attendent microenvironement in the first 24 hours of tumour regression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312064 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312064 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1372122 ncbi.nlm.nih.gov/bioproject/PRJNA1372122 ↗
project · from NCBI GEO
- PubMed 42298057 pubmed.ncbi.nlm.nih.gov/42298057 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312064 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |