Table 1_Time-adjusted direct medical costs of moderate-to-severe chronic graft-versus-host disease: a retrospective two-center cost analysis in Türkiye.docx

The determinants of the daily intensity of direct medical costs in moderate-to-severe cGVHD were examined.</p>Methods<p>Fifty patients treated between 2018 and 2023 at two private transplant centers in Türkiye were analysed retrospectively.

Because treatment durations varied, cost was modeled as an intensity per day of observation using a Gamma generalized linear model with a log link and a log-time offset and robust (HC1) standard errors. Cost components and mortality were examined as exploratory analyses.</p>Results<p>The mean total direct cost was 52,979 USD (SD 47,697), comprising medication (75.7%), inpatient (23.1%), and outpatient (1.3%) costs. Daily cost intensity was higher in male patients (cost ratio 2.163, 95% CI 1.451–3.224; +116% per day) and lower with older age (cost ratio 0.970 per year; −3.0% per year).